Both SMEs and large corporations are being disrupted by radical changing business models and digital transformation. Corporate innovation instruments become extremely critical for corporations to stay competitive. However, many SMEs don't have sufficient R&D budgets to invest in innovation. The concept of "Open Innovation" - working with innovative startups "MSMEs" - is one way to mitigate and overcome this deficiency. However, studies show that around 70% - 90% of all innovative MSME integrations with corporations failed. Now more than ever, success in corporate innovation is linked to successful integration of MSMEs / startups into APEC-based SMEs and corporations.